The benefit of HLA-matching in kidney transplantation
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چکیده
for 12th congress of the European Society of Organ Transplantation. October 2005, Geneva. Pas02 Pascual M, Theruvath T, Kawai T, et al. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002; 346: 580-90.Pau99 Paul LC. Perspectives in renal medicine. Chronic allograft nephropathy: an update. Kidney Int 1999;
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The Predictive Value of HLA-DR Matching and Cytokine Gene Polymorphisms in Renal Allograft Acute Rejection: A Living-unrelated Donor (LURD) Study
Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (LURD) kidney transplantation. Methods: A total of 42 renal transplants pe...
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c r c s p r d l g t c e t s t A p m s t i i NTRODUCTION istocompatibility testing is an essential component of a uccessful kidney transplant program for two fundamenal reasons. First, human leukocyte antigens (HLA) play central role in the cellular and humoral immune reponses that determine the outcome of a transplant. econd, the extensive polymorphism of HLA poses a ajor barrier to successful ...
متن کاملSuperiority of B locus matching over other HLA matching in renal graft survival.
Graft survival after 348 consecutive first cadaver-donor renal transplants was significantly improved by HLA matching when recipients who had received pretransplant blood transfusions were matched with their kidney donor for two HLA-B locus antigens. No other type of HLA matching significantly improved graft survival in transfused recipients nor did any type of HLA matching in non-transfused re...
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Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...
متن کاملHLA matching and cadaver kidney transplantation — status 1984
The effect of HLA matching on cadaver kidney graft survival was analysed in over 9000 transplants. Matching for HLA-A and -B accounted for an improvement of 8% in the one-year survival rate, matching for HLA-DR for 10%, and matching for HLA-B + DR for 19%. The matching effect of the HLA-B and HLA-DR loci was additive. Patients without pre-transplant transfusions had lower graft survival rates t...
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